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When the Brain’s Uncertainty computer goes offline: New Human Evidence for Thalamic Regulation of Decision-Making

When the Brain’s Uncertainty computer goes offline: New Human Evidence for Thalamic Regulation of Decision-Making

An Elegant Natural Experiment The study by Mackenzie et al. (2025, bioRxiv) represents a particularly clever approach to understanding human thalamic function. Rather than relying on correlational neuroimaging, the researchers capitalized on an unintended consequence...
PAPER ALERT: A New Model for Mediodorsal-Prefrontal Interactions

PAPER ALERT: A New Model for Mediodorsal-Prefrontal Interactions

In our ongoing quest to understand how the brain enables flexible cognition, the mediodorsal (MD) thalamus and its dialogue with the prefrontal cortex (PFC) have emerged as central players. Following a series of modeling papers from our lab—including Wei-Long Zheng’s...